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  • Title: Antiviral effect of the extract of culture medium of Lentinus edodes mycelia on the replication of herpes simplex virus type 1.
    Author: Sarkar S, Koga J, Whitley RJ, Chatterjee S.
    Journal: Antiviral Res; 1993 Apr; 20(4):293-303. PubMed ID: 8387258.
    Abstract:
    An extract of culture medium of Lentinus edodes mycelia, JLS-S001, significantly blocked the release of infectious herpes simplex virus type 1 (HSV-1) from African green monkey kidney cells. The block in replication was not due to the effect of JLS-S001 on the adsorption and penetration of HSV-1 to the monkey kidney cells. This observation was supported by the fact that JLS-S001 had no significant effect on the expression of virus-specific nucleocapsid proteins in the treated cells. Furthermore, electron microscopy demonstrated the presence of nucleocapsids within the nuclei of the infected and JLS-S001-treated cells. However, the expression of glycoproteins B, C, D, E and I was reduced in the JLS-S001-treated cells. These results suggested that JLS-S001 blocked HSV-1 replication at a late stage in virus replication cycle probably in the assembly and budding of nucleocapsids and subsequent egress from the treated cells.
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