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  • Title: In vitro synergistic activity between ofloxacin and ansamycins against Mycobacterium leprae.
    Author: Dhople AM, Ibanez MA, Gardner GD.
    Journal: Arzneimittelforschung; 1993 Mar; 43(3):384-6. PubMed ID: 8387790.
    Abstract:
    The antimicrobial effects of ofloxacin, alone and in combination with either rifampicin or rifabutin, were evaluated against M. leprae, using in vitro cell-free culture system. The minimum inhibitory concentration (MIC) of ofloxacin against M. leprae was 1.5 micrograms/ml, while MICs of rifampicin and rifabutin were 0.4 and 0.2 microgram/ml, respectively. Combination of 0.375 microgram/ml ofloxacin and 0.05 microgram/ml of rifabutin exhibited synergistic bactericidal activity while the effect of combination of 0.75 microgram/ml ofloxacin and 0.2 microgram/ml rifampicin was additive bactericidal. Thus, combination of ofloxacin and rifabutin deserves further attention in multi-drug therapy of leprosy.
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