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  • Title: Whole mouse measurement of paramagnetism-loss of nitroxide free radical in lung with a L-band ESR spectrometer.
    Author: Takeshita K, Utsumi H, Hamada A.
    Journal: Biochem Mol Biol Int; 1993 Jan; 29(1):17-24. PubMed ID: 8387846.
    Abstract:
    Paramagnetism-loss of nitroxide radical in lung of whole mouse was characterized using L-band ESR technique. The nitroxide, hydroxy-TEMPO, which had been injected trans-tracheally into mouse lung was confirmed to lose its paramagnetism in one electron reduction. The reduction activity remained even after lavage of lung. The reduction was inhibited by N-ethylmaleimide, a membrane-permeable sulfhydryl-blocker, though direct reduction of the radical by sulfhydryls was not observed in vitro. Sulfhydryl-blockers floating in membranes also inhibited the reduction, depending on their chain length. The results indicate that the reduction may be done within plasma membranes of alveolar epithelial cells.
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