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  • Title: Copper(II)-albumin complex can activate hydrogen peroxide in the presence of biological reductants: first ESR evidence for the formation of hydroxyl radical.
    Author: Ozawa T, Ueda J, Hanaki A.
    Journal: Biochem Mol Biol Int; 1993 Feb; 29(2):247-53. PubMed ID: 8388292.
    Abstract:
    Copper(II)-albumin complex did not directly react with hydrogen peroxide (H2O2). However, Cu(II)-albumin complex was easily reduced to Cu(I) complex by some biological reductants such as L-cysteine and L-ascorbic acid. Cu(I) complex thus formed could react with H2O2 to give hydroxyl radical (.OH) which was detected by electron spin resonance (ESR) spectroscopy using some water-soluble spin-traps. This result gives the first ESR evidence for the formation of OH radical by the reaction of Cu(II)-albumin with H2O2 in the presence of biological reductants.
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