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  • Title: Antithrombotic activity and its relationship to in vitro anticoagulant effects.
    Author: Gray E, Padilla A, Barrowcliffe TW.
    Journal: Haemostasis; 1993 Mar; 23 Suppl 1():99-102. PubMed ID: 8388358.
    Abstract:
    Antithrombotic activities of low molecular weight heparins (LMWHs) in a venous stasis thrombosis model, when compared to unfractionated heparin (UFH), correlated better with anti-IIa activities and inhibition of thrombin generation than with anti-Xa activities. The relative antithrombotic potencies of LMWHs were closer to inhibitory activity in thrombin generation with platelet-poor plasma than platelet-rich plasma. Comparing activities in intrinsic and extrinsic systems, higher concentrations of heparins were required in vitro to inhibit intrinsic thrombin generation than extrinsic thrombin production; however, higher doses were required to prevent in vivo thrombotic events initiated via the extrinsic pathway.
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