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  • Title: Significance of a newly identified attenuating mutation in Sabin 3 oral poliovirus vaccine.
    Author: Mento SJ, Weeks-Levy C, Tatem JM, Gorgacz EJ, Waterfield WF.
    Journal: Dev Biol Stand; 1993; 78():93-9; discussion 99-100. PubMed ID: 8388835.
    Abstract:
    Sequence analysis of poliovirus vaccine RNA has resulted in the identification of a new point mutation at position 2493 in Sabin 3. cDNA-derived Sabin 3 virus whose genome includes the new mutation has phenotypic properties expected for a vaccine strain. Virus engineered to contain a single base substitution at 2493 has lost the small plaque phenotype, and low neurovirulence characteristics normally associated with Sabin poliovirus strains. The significance of these observations and a potential relationship to the frequency of vaccine-associated poliomyelitis are described.
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