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  • Title: Murine cytomegalovirus interacts with major histocompatibility complex class I molecules to establish cellular infection.
    Author: Wykes MN, Shellam GR, McCluskey J, Kast WM, Dallas PB, Price P.
    Journal: J Virol; 1993 Jul; 67(7):4182-9. PubMed ID: 8389923.
    Abstract:
    The expression of stable, correctly folded major histocompatibility complex class I molecules conferred susceptibility to murine cytomegalovirus (MCMV) in cells which were previously resistant to infection, demonstrating that these molecules interact critically with MCMV to initiate infection. All class I molecules could potentiate MCMV infection but H-2Dd and Kb molecules were most efficient. Monoclonal antibodies specific for the alpha 1 and/or alpha 2 domains of Dd and Kb inhibited infection. Infection of L cells transfected with hybrid major histocompatibility complex class I molecules demonstrated that allelic control of susceptibility to MCMV mapped to the alpha 1 domain of Dd when in correct configuration with the alpha 2 and alpha 3 domains. In MCMV-resistant RMA-S cells, an improvement in the conformation of class I molecules introduced susceptibility to infection.
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