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  • Title: An African swine fever virus gene with similarity to the proto-oncogene bcl-2 and the Epstein-Barr virus gene BHRF1.
    Author: Neilan JG, Lu Z, Afonso CL, Kutish GF, Sussman MD, Rock DL.
    Journal: J Virol; 1993 Jul; 67(7):4391-4. PubMed ID: 8389936.
    Abstract:
    An open reading frame, LMW5-HL, in the African swine fever virus genome displays a high degree of similarity to the proto-oncogene bcl-2 and, to a lesser degree, the Epstein-Barr virus gene BHRF1. A highly conserved central region is found in all three proteins. LMW5-HL encodes a protein of 18 kDa that is present in infected porcine macrophages at both early and late times postinfection. The similarity of LMW5-HL to bcl-2 and BHRF1 suggests a role for it in cell maintenance during productive or persistent viral infection.
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