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  • Title: [Interaction of NAD with the GABA-ergic system of the rat brain].
    Author: Fomenko AI, Parkhomets PK, Donchenko GV, Stepanenko SP.
    Journal: Vopr Med Khim; 1993; 39(2):21-3. PubMed ID: 8390124.
    Abstract:
    After administration of corazole content of gamma-aminobutyric acid (GABA) was increased in the rat brain within 2 min and 10 min by 28% and 80%, respectively. Content of the GABA was distinctly decreased in the prespastic phase. During this period specific binding of 3H-muscimol to the GABA receptors was decreased. NAD at concentrations 10(-6) M and 10(-7) M activated the GABA receptors and inhibited binding of 14C-GABA to the synaptosomes of both intact rats and the animals treated with the convulsant agent. NAD appears to cause an effect as an inhibitory neurotransmitter at the postsynaptic level.
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