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  • Title: Distribution of the iron-heme displacement as resulting from myoglobin conformational substrates: an AOM approach to the interpretation of the EPR spectra.
    Author: Bizzarri AR, Bacci M, Cannistraro S.
    Journal: Biophys Chem; 1993 Apr; 46(2):117-29. PubMed ID: 8390307.
    Abstract:
    The electron paramagnetic resonance (EPR) low-temperature spectra of high spin ferric myoglobin samples in different solvent composition have been analyzed in terms of a distribution of the energy differences delta 1 and delta 2 for the iron low-lying electronic states. The widths of these distributions, which are found to be dependent on the solvent composition, have been correlated to the presence of a frozen ensemble of conformational substrates. A dedicated analysis based on the angular overlap method (AOM) has allowed us to work out a quantitative relationship between the delta 1 and delta 2 distributions and the spread of the iron-heme displacement; this being a structural parameter relevant for the biological functionality of the protein. The observed dependence of the iron-heme displacement distribution on the solvent composition is discussed.
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