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  • Title: Insulin stimulates hydrolysis of plasmanylinositol-glycan and phosphatidylinositol-glycan in rat adipocytes. Insulin-induced generation of inositol glycan, alkylacylglycerol, and diacylglycerol.
    Author: Suzuki S, Taneda Y, Hirai S, Satoh Y, Toyota T.
    Journal: Diabetes; 1993 Jul; 42(7):988-94. PubMed ID: 8390376.
    Abstract:
    Insulin binding to its receptor has been known to induce hydrolysis of phosphatidylinositol-glycan and release inositol-glycan and diacylglycerol, two putative second messengers of insulin actions. We metabolically labeled and purified PIG in rat cultured adipocytes. The treatment of [3H]glycerol-labeled PIG with phosphatidylinositol-specific phospholipase C released [3H]glycerol-labeled DAG and [3H]glycerol-labeled 1-alkyl,2-acyl-glycerol, suggesting that PIG has not only PIG but also plasmanylinositol-glycan moiety. Insulin induced hydrolysis of PIG/PMIG and generation of IG, DAG, and AAG in a dose-dependent manner. This report shows the first demonstration of insulin-sensitive PMIG in rat adipocytes. These results provide evidence that insulin-induced generation of IG, DAG, and AAG might be early events in the insulin-signaling mechanism in rat adipocytes, and insulin-releasable AAG seems to mediate some actions of insulin.
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