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  • Title: Immunity to lymphoid tumors in syngeneic mice by immunization with mitomycin C-treated cells.
    Author: Benjamini E, Fong S, Erickson C, Leung CY, Rennick D, Scibienski RJ.
    Journal: J Immunol; 1977 Feb; 118(2):685-93. PubMed ID: 839074.
    Abstract:
    Immunization of mice with syngeneic mitomycin C-treated lymphoid tumor cells (EL-4 and S49A) conferred a high degree of immunity to transplantation with viable tumor cells in syngeneic animals. The development of this immunity was paralleled by the development of specific cell-mediated cytotoxicity; no anti-tumor antibodies could be detected in the immunized animals. In contrast to the high immunoprophylactic capacity of mitomycin C-treated cells, attempts to utilize these cells for immunotherapy were unsuccessful. Preliminary experiments did not reveal antigenic differences between mitomycin C-treated and untreated tumor cells.
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