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  • Title: [Amyotrophic lateral sclerosis--indications of increased antiretroviral seroreactivity without obvious epidemiology].
    Author: Westarp ME, Bartmann P, Hoff-Jörgensen R, Clausen J, Rasmussen H, Kornhuber HH.
    Journal: Nervenarzt; 1993 Jun; 64(6):384-9. PubMed ID: 8392664.
    Abstract:
    Of 25 male and 13 female patients diagnosed as sporadic cases of amyotrophic lateral sclerosis between 1989 and 1992, 17 had reproducible serum antibodies against human foamy virus (HFV = human spuma retrovirus, HSRV). HFV-positive ALS patients had higher IgG3 concentrations than HFV-negatives (P < 0.05) and competed better on maedi-visna retroviral antigen than HFV-negatives or controls (P < 0.05), but did not differ otherwise. Two HFV-positive patients were living in the same building; two other ALS patients lived within 300 m of one another, and three HFV gag reactive men (2 ALS, 1 control) were living in neighbouring villages. These were the closest geographic clusters found among current patients. We summarize recent findings compatible with a pathogenetic role for endogenous and/or exogenous retroviral sequences in adult motor neuron disease, and confirm a male preponderance as well as an inverse correlation between survival time and age at onset.
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