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  • Title: The paraoxonase polymorphism in a Saudi Arabian population.
    Author: Nogueira CP, Evans DA, La Du BN.
    Journal: Pharmacogenetics; 1993 Jun; 3(3):144-9. PubMed ID: 8392888.
    Abstract:
    The paraoxonase polymorphism was analysed in the serum of 248 individuals from Saudi Arabia. The phenotyping method used was one based on the ratio of paraoxonase/arylesterase, described in earlier studies. The distribution of this ratio in the sample was trimodal and it provided a good resolution for the identification of three phenotypes: A-homozygotes with low activity; B-homozygotes with high activity; AB-the corresponding heterozygotes, with intermediate activity. Gene frequencies were 0.7296 for the allele A with low activity and 0.2704 for the allele B with high activity. These frequencies are close to those observed in Caucasian samples from North America and Europe. Phenotypic frequencies in the sample fit the Hardy-Weinberg equilibrium.
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