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  • Title: Comparison of ubiquinol and cytochrome c terminal oxidases. An alternative view.
    Author: Musser SM, Stowell MH, Chan SI.
    Journal: FEBS Lett; 1993 Jul 26; 327(2):131-6. PubMed ID: 8392948.
    Abstract:
    There have been numerous instances in the recent literature where the properties of ubiquinol and cytochrome c terminal oxidases are compared. Here we specifically examine the cytochrome bo3-type ubiquinol oxidase from Escherichia coli and the cytochrome aa3-type cytochrome c oxidases. A second redox-active copper site (CuA) is present only in the cytochrome c oxidases and the physiological electron donors for the two enzymes are different (ubiquinol-8 vs. ferrocytochrome c). In our opinion, these differences are significant and most likely indicate that distinct turnover mechanisms are operative in the two enzymes.
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