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  • Title: [Possible involvement of a recently discovered human retrovirus in idiopathic immunologic disorders, including Sjögren syndrome (autoimmune exocrinopathy)].
    Author: Fermin CD, Garry RF.
    Journal: HNO; 1993 May; 41(5):239-49. PubMed ID: 8392992.
    Abstract:
    Recent studies have suggested that newly-discovered human retroviruses may contribute to the pathogenesis of several immunological diseases. We linked a human intracisternal A-type retroviral particle (HIAP) to systemic autoimmune diseases, such as Sjögren's Syndrome. A-type retroviruses are envelope-deficient, a property that may contribute to their pathobiology and epidemiology. Potential mechanisms by which a defective retrovirus could induce immune dysfunctions are discussed.
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