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  • Title: Antigen processing mutant T2 cells present viral antigen restricted through H-2Kb.
    Author: Zhou X, Glas R, Liu T, Ljunggren HG, Jondal M.
    Journal: Eur J Immunol; 1993 Aug; 23(8):1802-8. PubMed ID: 8393799.
    Abstract:
    Cytotoxic T lymphocytes (CTL) recognize foreign antigens as short peptides presented by class I molecules of the major histocompatibility complex (MHC). T2 cells are profoundly defective in the presentation of endogenously synthesized antigens to CTL due to a deletion of MHC class II-encoded genes for transporters associated with antigen presentation (TAP1/TAP2). Surprisingly, we here demonstrate that T2 cells, after infection with Sendai virus, are readily killed by H-2Kb restricted CD8+ T cells. In contrast to classical class I-mediated antigen presentation, the presentation of Sendai virus antigen in T2Kb cells is brefeldin A (BFA) insensitive. The present findings may suggest the presence of an alternative pathway for MHC class I-mediated antigen presentation in T2 cells.
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