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  • Title: Displacement of bilirubin from human albumin by three diuretics.
    Author: Wennberg RP, Rasmussen F, Ahlfors CE.
    Journal: J Pediatr; 1977 Apr; 90(4):647-50. PubMed ID: 839388.
    Abstract:
    The interaction of three diuretics with bilirubin-albumin complexes was studied using the peroxidase assay, erythrocyte uptake, and sephadex gel filtration. On a molar basis, each diuretic was as potent or more potent than sulfisoxazole in displacing bilirubin from albumin. Furosemide and ethacrynic acid, when used at the recommended dosage (1 mg/kg), would probably not produce a significant increase in free bilirubin in most infants. Chlorothiazide could introduce a significant risk to jaundiced infants because of the higher dosage required.
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