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  • Title: Retrospective analysis of prognostic significance of the estrogen-inducible pS2 gene in male breast carcinoma.
    Author: Kardaś I, Seitz G, Limon J, Niezabitowski A, Ryś J, Theisinger B, Welter C, Blin N.
    Journal: Cancer; 1993 Sep 01; 72(5):1652-6. PubMed ID: 8394203.
    Abstract:
    BACKGROUND: The estrogen-inducible pS2 gene, originally isolated from a breast cancer cell line, is correlated with hormone-dependent female breast tumors and its expression is associated with longer overall and disease-free survival. METHODS: The authors have investigated 38 samples of carcinomas of the male breast for pS2 expression by using a monoclonal antibody. The immunostaining was compared with clinical data, in particular, to the progesterone receptor status, to assess a possible prognostic value of this parameter. RESULTS: Although most cases (27 of 38) were immunopositive (i.e., above the 5th percentile of immunoreactive cells), no correlation with tumor grade and survival was notable. CONCLUSIONS: Therefore, on the contrary to the situation in female breast cancer, pS2 activity failed to constitute a new prognostic parameter in male breast carcinomas.
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