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  • Title: Role of adenosine in heterosynaptic, posttetanic depression in area CA1 of hippocampus.
    Author: Grover LM, Teyler TJ.
    Journal: Neurosci Lett; 1993 May 14; 154(1-2):39-42. PubMed ID: 8395668.
    Abstract:
    Conditioning stimulation of afferent fibers in hippocampal area CA1 produced heterosynaptic, posttetanic depression (PTD) of responses evoked by stimulation of an independent set of afferent fibers. PTD was present within 5 s of conditioning stimulation, amounted to a 60-80% reduction of excitatory postsynaptic potentials (EPSPs), and required a period of 3-5 min for recovery. Antagonists of A1 adenosine receptors substantially reduced PTD. Adenosine released into, or formed in, the extracellular space during conditioning stimulation may diffuse within the slice to depress evoked release of glutamate.
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