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  • Title: In vitro activity of cefodizime (HR-221) in combination with beta-lactamase inhibitors.
    Author: Segatore B, Perilli M, Franceschini N, Setacci D, Oratore A, Amicosante G.
    Journal: J Chemother; 1993 Jun; 5(3):147-50. PubMed ID: 8396624.
    Abstract:
    Cefodizime (formerly HR221) was tested either for in vitro microbiological activity or for its stability to beta-lactamases in the presence of two beta-lactamase inhibitors (clavulanic acid, tazobactam). Cefodizime was a poor substrate of class C enzymes but hyperproducer strains were generally resistant with or without a beta-lactamase inhibitor used in combination. On the contrary, class A enzymes were able to hydrolyze cefodizime. However, strains expressing class A beta-lactamase were susceptible to cefodizime in combination with clavulanic acid.
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