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  • Title: A common proviral integration region, fit-1, in T-cell tumors induced by myc-containing feline leukemia viruses.
    Author: Tsujimoto H, Fulton R, Nishigaki K, Matsumoto Y, Hasegawa A, Tsujimoto A, Cevario S, O'Brien SJ, Terry A, Onions D.
    Journal: Virology; 1993 Oct; 196(2):845-8. PubMed ID: 8396812.
    Abstract:
    Feline leukemia viruses carrying transduced v-myc genes (myc-FeLV) induce tumors of clonal origin, suggesting that activated myc alone is not sufficient for tumorigenesis. To investigate the hypothesis that insertional mutagenesis plays a role by activating genes which collaborate with v-myc, we looked for evidence of common proviral integration sites in these tumors. By inverse polymerase chain reaction we identified a 6-kb domain, designated fit-1, in which FeLV proviruses were inserted in four of nine (44%) T-cell tumors induced by myc-FeLV. The fit-1 locus was mapped to feline chromosome B2 and appears to be distinct from known oncogenes located on this chromosome. Fit-1 represents a novel common proviral integration region which may harbor a cellular gene which acts in concert with the myc gene in T-cell tumorigenesis.
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