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  • Title: Functional analysis of the human IGF-I gene promoters.
    Author: Steenbergh PH, Jansen E, van Schaik FM, Sussenbach JS.
    Journal: Mol Reprod Dev; 1993 Aug; 35(4):365-7. PubMed ID: 8398115.
    Abstract:
    The two putative promoter regions of the human insulin-like growth factor-I (IGF-I) gene, located upstream of the two alternatively used leader exons 1 and 2, were tested for promoter activity in transient transfection assays. Both regions were shown to possess promoter activity. The results further indicate cell-type-specific regulation of the activities of the two promoters in endogenously IGF-I producing human cell lines of different origin.
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