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  • Title: Detection of ribosomal RNA during the cell cycle in Ehrlich tumour cells by electron microscope in situ hybridization.
    Author: Thiry M.
    Journal: Eur J Morphol; 1993; 31(1-2):13-6. PubMed ID: 8398547.
    Abstract:
    The fine spatial distribution of rRNA within Ehrlich tumour cells has been investigated during the cell cycle by in situ hybridization with a biotinylated probe. In interphase cells, rRNA was essentially detected in the ribosome-rich cytoplasmic regions and in the three main nucleolar components. In mitotic cells, besides the presence, as expected, of rRNA in the ribosome-rich spaces, evident label was observed over material situated around and between the chromosomes during anaphase and telophase as well as over the reforming nucleoli during telophase.
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