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  • Title: The effect of pH on the aerobic and hypoxic cytotoxicity of SR4233 in HT-29 cells.
    Author: Skarsgard LD, Skwarchuk MW, Vinczan A, Chaplin DJ.
    Journal: Br J Cancer; 1993 Oct; 68(4):681-3. PubMed ID: 8398693.
    Abstract:
    We have observed that low pH can substantially potentiate the cytotoxic effect of the bioreductive drug SR4233 in aerobic HT-29 human tumour cells. No such potentiation was observed under hypoxic conditions. This pH effect might be relevant both to the therapeutic effectiveness and to the normal tissue toxicity of this new agent.
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