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  • Title: Effect of various n-3/n-6 fatty acid ratio contents of high fat diets on rat liver and heart peroxisomal and mitochondrial beta-oxidation.
    Author: Vamecq J, Vallee L, de la Porte PL, Fontaine M, de Craemer D, van den Branden C, Lafont H, Grataroli R, Nalbone G.
    Journal: Biochim Biophys Acta; 1993 Oct 13; 1170(2):151-6. PubMed ID: 8399339.
    Abstract:
    The present work extends tissue investigations previously performed in rat gastric mucosa on lipid metabolism alterations caused by n-3 and n-6 fatty acid-enriched diets. Liver and heart tissues are here studied and demonstrated to undergo, upon exposure to high fat diets with various n-3/n-6 fatty acid ratio contents, biochemical and morphological changes which may be enumerated as follows: (1) Rat liver peroxisomal prostaglandin E2, fatty acid but not bile acid beta-oxidation rates are enhanced, especially upon the diet with the higher n-3/n-6 fatty acid ratio. Mitochondrial beta-oxidation rates are little or not affected by the high fat diets. (2) Rat liver carnitine acyltransferases are stimulated by the high fat diets, the more rich the n-3 fatty acid content, the more pronounced the stimulatory effect. (3) Rat heart peroxisomal and mitochondrial beta-oxidation rates were increased in animals receiving the n-3 fatty acid-enriched diet. At a low n-3/n-6 fatty acid ratio content of the diet, these oxidizing rate values were in control range. The carnitine acyltransferase activities were increased in rat heart to different extents, depending on the n-3/n-6 fatty acid ratio content of the diet. (4) Ultrastructural examination and morphometric determinations on hepatocytes from rats receiving the diets with the lowest and the highest n-3/n-6 fatty acid ratio contents disclose that in the latter case the numbers and fractional volumes of peroxisomes and mitochondria are significantly higher than in the former case.
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