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  • Title: [Mechanism of temperature uncoupling of the sarcoplasmic reticulum calcium pump: change in the functional properties and structural state of the enzyme molecule].
    Author: Geĭmonen ER, Rubtsov AM, Boldyrev AA.
    Journal: Biokhimiia; 1993 Aug; 58(8):1296-306. PubMed ID: 8399778.
    Abstract:
    The effect of short-term thermal treatment causing the uncoupling of the hydrolytic and transport functions of skeletal muscle sarcoplasmic reticulum Ca-ATRase on the conformational state of the enzyme and the physico-chemical characteristics of the membrane lipid bilayer has been studied. It has been found that enhanced passive permeability of the membrane for Ca2+ is the main cause for the decreased efficiency of the Ca-pump function. Thermal treatment induced no changes in the conformation of the hydrophilic domain of the Ca-ATRase; however, the accessibility of the transmembrane hydrophobic domain for some solutes turned out to be restricted, the microviscosity of the lipid bilayer decreased and the protein-lipid and protein-protein interactions within the membrane disturbed after the heat exposure.
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