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  • Title: Production of interleukin-1, interleukin-6, and tumor necrosis factor alpha in the uterus of pseudopregnant mice.
    Author: Choudhuri R, Wood GW.
    Journal: Biol Reprod; 1993 Sep; 49(3):596-603. PubMed ID: 8399854.
    Abstract:
    Pseudopregnant mice were produced by mating normal cycling females with a vasectomized male. Interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF alpha) mRNA and bioactivity were detected between Days 1 and 8 in untreated pseudopregnant mice and during oil-induced decidualization. High concentrations of IL-1, IL-6, and TNF alpha mRNA and bioactivity were detected in the uterus within 12 h after mating, and both mRNA and bioactivity decreased progressively through Day 3. Peaks of IL-1, IL-6, and TNF alpha bioactivity were detected between Days 4 and 8. Oil-induced decidualization was associated with increased and prolonged production of IL-1 and IL-6 and decreased production of TNF alpha relative to these values in uninjected controls. The dynamics of cytokine production in pseudopregnant mice were similar to those previously observed in pregnant mice.
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