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  • Title: [An assessment of the differences in the reaction of the left and right heart ventricles to a long-term rise in systemic arterial pressure in experimental renoprival arterial hypertension in rabbits].
    Author: Frolov VA, Drozdova GA, Kazanskaia TA, Ramdavon P.
    Journal: Biull Eksp Biol Med; 1993 Jul; 116(7):21-3. PubMed ID: 8400167.
    Abstract:
    Different parameters of the function of the left and right heart ventricles were investigated in rabbits with renoprival arterial hypertension during a period of 52 weeks from the moment of modelling the process. As a result, this process was divided into 3 stages: 1. The establishment of compensation (1-4 weeks); 2. Compensation (6-10 weeks); 3. Decompensation (22-52 weeks). In mathematical prognosis of the time-course changes in the parameters associated with different stages of the process, the prognostic data were shown to be close to the experimental ones during prognosis for the left ventricle in the second stage, and for the right ventricle in the first stage. While prognosing for the left ventricle in the first stage and for the right ventricle in the second stage, the data obtained were significantly different from the experimental ones. These results suggest a conclusion that the right ventricle adapts itself to cardiac overload quicker than the left ventricle, but it also gets "worn out" quicker than the latter due to the conditions of "rigid" functioning in the second stage of the process when the adaptive potentials of the heart are limited.
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