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  • Title: [The sodium oxybutyrate and nooglutil correction of dopamine release in the striatum of prenatally alcoholized rat pups].
    Author: Kovalev GI, Budygin EA, Gaĭnetdinov RR, Kudrin VS, Trofimov SS, Ostrovskaia RU.
    Journal: Biull Eksp Biol Med; 1993 Jul; 116(7):56-8. PubMed ID: 8400184.
    Abstract:
    The influence of prenatal exposure to ethanol on endogenous Dopamine (DA) release from perfused isolated striata of 20-day-old rats was studied, as well as its correction by nootropic drugs: sodium hydroxy butyrate and nooglutil. Administration of 20% ethanol per os at a daily dose of 5 mg per kg during the entire period of pregnancy led to a significant decrease in basal and K(+)-evoked DA efflux. Hydroxy-butyrate and Nooglutil (50 and 25 mg per kg, subcutaneously, daily from the 8th to the 20th day of life) normalized these alterations in alcohol-exposed neonates, although their effects on the offsprings of non-alcoholized rats were opposite. The probable neurochemical targets of ethanol and nootropics are discussed.
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