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  • Title: Alterations of guanine nucleotide-binding proteins in post-mortem human brain in alcoholics.
    Author: Ozawa H, Katamura Y, Hatta S, Saito T, Katada T, Gsell W, Froelich L, Takahata N, Riederer P.
    Journal: Brain Res; 1993 Aug 20; 620(1):174-9. PubMed ID: 8402195.
    Abstract:
    Qualitative and quantitative alterations of G proteins in membrane preparations from parietal and temporal cortex regions in post-mortem brains obtained from alcoholics and controls matched with respect to age and post-mortem delay were investigated by Western-blotting with polyclonal antibodies against specific G protein subunits and functional photoaffinity GTP binding. Quantitative immunoblotting showed that only Gs alpha (52 kDa species) in temporal cortex was significantly decreased (30%, P < 0.05) in alcoholics compared with controls. Moreover, ethanol-stimulated photoaffinity GTP labeling of Gs alpha and Gi/o alpha was decreased in alcoholics in both cortex regions. These results suggest that disturbances of G protein-mediated signal transduction may be involved in the pathophysiology of alcoholics.
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