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  • Title: Immunohistopathological spectrum in cutaneous tuberculosis.
    Author: Sehgal VN, Gupta R, Bose M, Saha K.
    Journal: Clin Exp Dermatol; 1993 Jul; 18(4):309-13. PubMed ID: 8403463.
    Abstract:
    Granulomas of lupus vulgaris were characterized by a raised CD4+/CD8+ ratio, while in scrofuloderma this was significantly decreased. Tuberculosis verrucosa cutis showed intermediate changes. These immunological variations suggest that cutaneous tuberculosis forms a spectrum with strong cell-mediated immunity seen in lupus vulgaris, and weaker cell-mediated responses in scrofuloderma; tuberculosis verrucosa cutis is intermediate between the two.
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