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  • Title: Early detection of aminoglycoside nephrotoxicity with urinary beta-2-microglobulin.
    Author: Schentag JJ, Sutfin TA, Plaut ME, Jusko WJ.
    Journal: J Med; 1978; 9(3):201-10. PubMed ID: 84037.
    Abstract:
    We used a radioimmunoassay to evaluate the changes in the urinary excretion of beta2-microglobulin (beta2M) in 21 patients receiving aminoglycosides for treatment of infection. Excretion of this protein rose to a peak at least 5 times the baseline value in the urine, and declined rapidly to control values after drug administration ceased. In six patients who developed aminoglycoside nephrotoxicity, urinary beta2M excretion rose 5 days or more before serum creatinine rose, and 5 of 6 nephrotoxic patients excreted more than 50 mg/day (normal, less than 0.1 mg/day). Urinary beta2M is a non-specific indication of renal tubular damage, but heralds aminoglycoside-induced damage before standard tests of kidney function change.
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