These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Protective effects of calcitonin gene-related peptide in different experimental models of gastric ulcers.
    Author: Clementi G, Amico-Roxas M, Caruso A, Cutuli VM, Maugeri S, Prato A.
    Journal: Eur J Pharmacol; 1993 Jul 06; 238(1):101-4. PubMed ID: 8405073.
    Abstract:
    Intravenous administration of calcitonin gene-related peptide (CGRP) prevented in a dose-dependent manner reserpine-induced gastric mucosal damage, but failed to affect the lesions produced by ethanol administration. In pylorus-ligated rats, CGRP significantly reduced gastric volume, total acid and peptic activity output as well as ulcer formation. These protective effects of CGRP were not present when rats were pretreated with cysteamine. Our data suggest that CGRP exerts its antisecretory and antiulcer activity, at least in part, by interfering with somatostatin transmission.
    [Abstract] [Full Text] [Related] [New Search]