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  • Title: Vitamin B6 deficiency causes activation of RNA polymerase and general enhancement of gene expression in rat liver.
    Author: Oka T, Komori N, Kuwahata M, Sassa T, Suzuki I, Okada M, Natori Y.
    Journal: FEBS Lett; 1993 Sep 27; 331(1-2):162-4. PubMed ID: 8405398.
    Abstract:
    The effect of vitamin B6 deficiency on the activity of RNA polymerase and expression of several mRNAs in rat liver was investigated. The activities of RNA polymerase I and II in the liver of vitamin B6-deficient rats were found to be higher than the control rats by 30%. The expression of several mRNAs, including mRNAs for beta-actin and glyceraldehyde-3-phosphate dehydrogenase, and the content of poly(A)+ RNA were also increased in vitamin deficiency. These observations suggest that vitamin B6 influences gene expression in the liver, at least in part, by modulating the activity of RNA polymerase.
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