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  • Title: Chromosomal localization and genomic cloning of the mouse alpha-tropomyosin gene Tpm-1.
    Author: Schleef M, Werner K, Satzger U, Kaupmann K, Jockusch H.
    Journal: Genomics; 1993 Aug; 17(2):519-21. PubMed ID: 8406508.
    Abstract:
    In vertebrates, the alpha-tropomyosin gene, Tpm-1, codes for at least 9 tropomyosin isoforms that are expressed by tissue-specific alternative splicing. Using interspecies backcrosses, we have localized Tpm-1 on mouse chromosome 9, cen-Cyp1a2-Tpm-1-Mod-1-Mylc-Scn5a, near the d-se region. The restriction fragment length variant used for chromosomal assignment, as well as other restriction fragments hybridizing to a 3'-specific alpha-tropomyosin cDNA probe in genomic Southern blots, was investigated by cloning 17.5-kb of Tpm-1. The same restriction patterns were observed, proving the identity of the mapped and the cloned gene. The identity was supported by sequencing the 3' end of the gene.
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