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  • Title: Effects of ribosome-inactivating proteins on Escherichia coli and Agrobacterium tumefaciens translation systems.
    Author: Girbés T, Barbieri L, Ferreras M, Arias FJ, Rojo MA, Iglesias R, Alegre C, Escarmis C, Stirpe F.
    Journal: J Bacteriol; 1993 Oct; 175(20):6721-4. PubMed ID: 8407849.
    Abstract:
    The effects of 30 type 1 and of 2 (ricin and volkensin) type 2 ribosome-inactivating proteins (RIPs) on Escherichia coli and Agrobacterium tumefaciens cell-free translation systems were compared with the effects on a rabbit reticulocyte translation system. The depurinating activity of RIPs on E. coli ribosomes was also evaluated. Only six type 1 RIPs inhibited endogenous mRNA-directed translational activity of E. coli lysates, with submicromolar 50% inhibitory concentrations. Four RIPs had similar activities on poly(U)-directed phenylalanine polymerization by E. coli ribosomes, and three RIPs inhibited poly(U)-directed polyphenylalanine synthesis by A. tumefaciens ribosomes, with submicromolar 50% inhibitory concentrations.
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