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Pubmed for Handhelds

PUBMED FOR HANDHELDS

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  • Title: Bleeding as presenting symptom of cholestasis.
    Author: van den Anker JN, Sinaasappel M.
    Journal: J Perinatol; 1993; 13(4):322-4. PubMed ID: 8410391.
    Abstract:
    Four infants with conjugated hyperbilirubinemia who were brought for treatment primarily because of a hemorrhage are reported. Underlying disorders included extrahepatic biliary atresia, choledochal cysts, and alpha 1-antitrypsin deficiency. Prodromal signs of disturbed coagulation and diminished bile excretion were not recognized. The increased bleeding tendency was probably caused by vitamin K deficiency, resulting from a combination of cholestasis-induced fat malabsorption, absence of vitamin K supplementation after birth, and low vitamin K intake as a result of breast feeding.
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