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  • Title: [Drug-induced syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Review of literature].
    Author: Verstraeten L, Dewier B, Montjoie C, Hassoun A.
    Journal: J Pharm Belg; 1993; 48(3):227-32. PubMed ID: 8410627.
    Abstract:
    The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is caused by an incapacity of plasmatic hypotonia to inhibit antidiuretic hormone (ADH) secretion. This phenomenon leads to a water retention and an expanded extracellular fluid volume, and secondary to a dilution of plasmatic sodium and also to a renal loss of sodium. The SIADH is a relatively rare syndrome, which may occur in various circumstances: central nervous system diseases, cancers, infections... Sometimes, it may be observed as a drug-related side effect: carbamazepine, chlorpropamide, antidepressors, anticancer drugs are particularly involved.
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