These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: An analysis of clinical studies of the use of crosslinked hyaluronan, hylan, in the treatment of osteoarthritis.
    Author: Adams ME.
    Journal: J Rheumatol Suppl; 1993 Aug; 39():16-8. PubMed ID: 8410879.
    Abstract:
    Viscosupplementation with hyaluronan is a safe modality for treating osteoarthritis (OA) of the knee, but it often requires many injections to achieve efficacy. This may result from insufficient elastoviscous properties of current hyaluronan preparations or too rapid egress from the joint. Because both of these properties would be improved by increasing the molecular weight of the substance, hylans, or crosslinked hyaluronans, were developed as therapeutic agents for viscosupplementation of osteoarthritic synovial fluid. This report reviews the results of 4 clinical trials in Germany that assessed the efficacy and safety of hylan G-F 20 (Synvisc).
    [Abstract] [Full Text] [Related] [New Search]