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  • Title: The effect of 15 (R) 15 methyl prostaglandin E2 on gastric acid secretion in duodenal ulcer patients.
    Author: Chen FW, Teck HS, Karim SM.
    Journal: Prostaglandins; 1977 Jan; 13(1):115-24. PubMed ID: 841099.
    Abstract:
    The effect of synthetic analogue 15 (R) 15 methyl PGE2 on basal and pentagastrin stimulated maximal acid output in 24 duodenal ulcer patients has been studied. The prostagoandin analogue in a single oral dose of 150 mug reduced both basal and maximum output. Basal acid output fell from a mean control value of 5.9 +/- 1.5 mEq/hr to 2.1 +/- 0.6 mEq/hr (p less than 0.05) and maximum acid output from 32.1 +/- 1.6 mEq/hr to 20.6 mEq/hr (p less than 0.001). The volume of gastric secretion did not alter significantly in the basal state but fell significantly in the maximally stimulated state after prostaglandin administration.
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