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  • Title: Infection by echoviruses 1 and 8 depends on the alpha 2 subunit of human VLA-2.
    Author: Bergelson JM, St John N, Kawaguchi S, Chan M, Stubdal H, Modlin J, Finberg RW.
    Journal: J Virol; 1993 Nov; 67(11):6847-52. PubMed ID: 8411387.
    Abstract:
    Anti-VLA-2 antibodies protected HeLa cells from infection by echoviruses 1 and 8 but not from infection by other echovirus serotypes. Echoviruses 1 and 8 bound to and infected nonpermissive hamster cells transfected with the alpha 2 subunit of human VLA-2. These results indicate that the human alpha 2 subunit is critical for infection by echoviruses 1 and 8 but that other echovirus serotypes must bind receptors other than VLA-2.
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