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  • Title: Herpes simplex virus thymidine kinase and specific stages of latency in murine trigeminal ganglia.
    Author: Jacobson JG, Ruffner KL, Kosz-Vnenchak M, Hwang CB, Wobbe KK, Knipe DM, Coen DM.
    Journal: J Virol; 1993 Nov; 67(11):6903-8. PubMed ID: 8411396.
    Abstract:
    From marker rescue, sequencing, transcript, and latency analyses of the thymidine kinase-negative herpes simplex virus mutant dlsactk and studies using the thymidine kinase inhibitor Ro 31-5140, we infer that the virus-encoded thymidine kinase is required in murine trigeminal ganglia for acute replication and lytic gene expression, for increasing the numbers of cells expressing latency-associated transcripts, and for reactivation from latent infection.
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