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  • Title: [Oral ciprofloxacin therapy in juvenile patients with cystic fibrosis--results of a prospective pilot study].
    Author: Sollich V, Klöditz E, Schuster R, Handrick W, Brömme S, Rumler W, Patsch R, Kharari H, Spencker FB.
    Journal: Kinderarztl Prax; 1993 Aug; 61(6):211-4. PubMed ID: 8411847.
    Abstract:
    Efficacy and safety of oral ciprofloxacin were studied in a prospective study at three cystic fibrosis centres, covering 24 in-patients suffering from cystic fibrosis and acute bronchopulmonary exacerbation. The patients were between 10 and 17 years of age. Pseudomonas infection was present in 75% of these patients. Despite frequent persistence of the pathogens, clinical improvement was noted in 75% of the treated children. A definite increase of the average MIC was not seen in 20 cases of persisting strains. No serious side effects occurred during the 14-day oral treatment course. Ciprofloxacin is a useful alternative to conventional parenteral treatment with antibiotics in patients suffering from cystic fibrosis and infections of the airways.
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