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  • Title: Inhibition of lipid peroxidation in rat brain by nifedipine and clorazepate after electrically induced seizures.
    Author: Kułak W, Sobaniec W, Sobaniec-Lotowska M.
    Journal: Mater Med Pol; 1993; 25(1):33-5. PubMed ID: 8412340.
    Abstract:
    The effect of nifedipine and clorazepate on the concentration of lipid peroxides (LP) in rat brain, and the characteristics of electrically induced seizures were assessed. A significant increase in the concentration of brain LP after electroshock was found. Both nifedipine (1.00 mg/kg per os) and clorazepate (20 mg/kg intraperitoneally) decreased the levels of LP in the rat brain after electroshock. Nifedipine combined with clorazepate brought an inhibition of LP formation and an additive anticonvulsant activity.
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