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  • Title: Pancreatic polypeptide stimulates corticosterone secretion by isolated rat adrenocortical cells.
    Author: Andreis PG, Tortorella C, Nussdorfer GG.
    Journal: Life Sci; 1993; 53(17):1353-6. PubMed ID: 8412501.
    Abstract:
    Pancreatic polypeptide (PP) dose-dependently enhanced both basal and submaximally ACTH-stimulated corticosterone production by dispersed zona fasciculata/reticularis cells of the rat adrenal gland. Conversely PP did not affect either basal or ACTH- and angiotensin-II-stimulated aldosterone and corticosterone secretion of zona glomerulosa cells. These findings could throw light on the physiological significance of the marked increase in the pancreatic release of PP during stresses.
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