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  • Title: Association between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-kappa B.
    Author: Kerr LD, Ransone LJ, Wamsley P, Schmitt MJ, Boyer TG, Zhou Q, Berk AJ, Verma IM.
    Journal: Nature; 1993 Sep 30; 365(6445):412-9. PubMed ID: 8413585.
    Abstract:
    The c-Rel protein is able to associate in vitro and in vivo with the TATA-binding protein (TBP) of the TFIID complex. Coexpression of TBP with c-Rel augments transactivation from the kappa B site in Drosophila Schneider cells. DNA-binding mutants of TBP not only fail to cooperate, but they repress transactivation by c-Rel. There may be a direct communication between kappa B enhancer binding proteins and basal transcription factors which leads to enhanced transcription.
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