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  • Title: Parallel genome analysis by two-dimensional DNA typing.
    Author: Mullaart E, de Vos GJ, te Meerman GJ, Uitterlinden AG, Vijg J.
    Journal: Nature; 1993 Sep 30; 365(6445):469-71. PubMed ID: 8413593.
    Abstract:
    By two-dimensional (2-D) DNA typing a restriction enzyme digest of genomic DNA can be resolved on the basis of both size and base-pair sequence and subsequently analysed by repeat probe hybridization to reveal sequence variants at multiple genomic sites in parallel. The system has been partly automated and allows for large-scale comparative analysis of complex genomes in a cost-effective manner.
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