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  • Title: Low follicular oestrogen levels in New Zealand women consuming high fibre diets: a risk factor for osteopenia?
    Author: Feng W, Marshall R, Lewis-Barned NJ, Goulding A.
    Journal: N Z Med J; 1993 Oct 13; 106(965):419-22. PubMed ID: 8414277.
    Abstract:
    AIMS: To study effects of anthropometry, diet and exercise on plasma 17 beta-oestradiol concentrations in healthy premenopausal women. METHODS: Fifty-five healthy female volunteers aged 19-29 (Mean (SD) = 22.2 (2.6) years) were studied. Anthropometric measurements were made, food intakes were estimated using a food frequency questionnaire, physical activity was assessed, menstrual histories were taken and blood 17 beta-oestradiol values were measured in the follicular and luteal phases of the menstrual cycle. RESULTS: Adiposity and dietary fat intake did not influence circulating plasma 17 beta-oestradiol but dietary fibre intake was negatively correlated with both follicular (r = -0.43, p < 0.001) and luteal (r = -0.28, p < 0.05) 17 beta-oestradiol concentrations. Follicular oestradiol values were abnormally low in 53% of the population. Subjects with high fibre intakes (> or = 25 g fibre daily) had significantly lower concentrations of 17 beta-oestradiol in the follicular phase of the menstrual cycle (p < 0.01). Physical activity was similar in groups consuming high and low fibre diets. Subjects with oligomenorrhoea or amenorrhoea (n = 7) had higher fibre intakes/energy (p < 0.05) than subjects with eumenorrhoea (n = 48). CONCLUSION: Our study suggests that healthy New Zealand women of premenopausal age have lower 17 beta-oestradiol levels on high fibre diets than on low fibre diets. Because hypoestrogenism is a known risk factor for osteoporosis we propose that high fibre intakes may influence bone mass adversely and be a risk factor for osteoporosis. The effects of high fibre intakes on bone mass warrant further investigation.
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