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  • Title: Prenatal toxicity of medroxyprogesterone acetate in rabbits, rats, and mice.
    Author: Andrew FD, Staples RE.
    Journal: Teratology; 1977 Feb; 15(1):25-32. PubMed ID: 841480.
    Abstract:
    Medroxyprogesterone acetate (MPA) was given once daily sc at 0.1-3,000 mg/kg/day for 3, 6, or 9 consecutive days during gestation days 7 to 15 to CD1 and A/J mice, and New Zealand (NZ) and Dutch Belted (DB) rabbits, and during days 8 to 16 to CD rats. Malformations attributable to MPA did not occur in fetuses of mice or rats exposed to the largest dosage tested. However, 1, 3, or 10 mg/kg on days 13 to 15 to NZ rabbits resulted in 6, 28, and 42% cleft palate, respectively. Comparable cleft palate frequencies were seen in DB offspring.
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